Rejuran (polynucleotide injection)

Injections of polynucleotides (PN), DNA-derived molecules, placed into the skin with many small injections. A 2024 review describes REJURAN as a prominent PN product in Asia. Studies report improvements in fine wrinkles, texture and elasticity, but a 2025 systematic review found only nine studies, of low-to-moderate quality.

Adults who want to improve skin texture, fine lines or skin quality and accept a series of injections with gradual, modest change.

The face is cleansed and numbed. PN is injected in small amounts across the treatment area with a fine needle, and the skin is cleaned.

Redness and swelling often last a few hours. Small bumps at the injection points are common at first and are usually temporary. Bruising is possible.

• Pain, redness and swelling at injection points
• Bruising and visible needle marks
• Small temporary bumps under the skin
• Rare: foreign-body granulomas (persistent lumps) or post-inflammatory darkening

• Do not rub or press the bumps unless the clinic tells you to
• Use gentle skin care and sunscreen for the next few days
• Contact the clinic if a lump, pain or redness gets worse